There is no guide for this game yet. But apparently it is EASY POINTS!
Tip by BILLY BADBONES on character upgrades :
Having played the game once on the easiest of the difficulty's I decided it would not be needed to upgrade any of the characters and just play the game using either Jonny's flame or The Things Slam attack. On the later levels you can upgrade one character fully, but instead of proceeding with the game, as soon as the achievement pops exit right away to dashboard and simply replay the last level until you get to the upgrade selection again.
Because you didn't save the game your credits will still be there and you can go ahead and upgrade the next character.
You can do this on any difficulty, and its worth a whopping 320 G's
Mr. Fantastic - 80 points
Upgrade all of Mr. Fantastic's Powers
Invisible Woman - 80 points
Upgrade all of the Invisible Woman's Powers
Human Torch - 80 points
Upgrade all of the Human Torch's Powers
Thing - 80 points
Upgrade all of The Thing's Powers
Hero - 120 points
Complete the game in normal difficulty mode.
Superhero - 160 points
Complete the game in Fantastic mode.
Doomed - 30 points
Defeat Dr. Doom
Skrull's Demise - 20 points
Defeat Super Skrull
Elemental Master - 20 points
Defeat Terrax
Skrull Slayer - 20 points
Complete Skrull Lair Level
Cold War Relic - 20 points
Complete Red Ghost Level
Wedding Crasher - 20 points
Complete New York Level
Rock Crusher - 20 points
Complete Terrax Level
Arctic Explorer - 20 points
Complete Military Base Level
Shanghai Success - 30 points
Complete Shanghai Level
Treasure Hunter - 80 points
Successfully unlocked all content in game.
Fantastic Four - 60 points
Find all of the silver four symbols.
Doom Tracker - 40 points
Find all of Doom’s Spy bots in the game.
Assist - 20 points
Successfully execute a 2-player fusion attack.