I tried the new sandbox mode. No timer, no cases, got 18 achievements for a total of 360 gamerscore in just a few hours. So getting 100k kills with no timer, and all the areas already unlocked shouldn't be too much of a problem.
I love the gameplay in dead rising, but the whole timer things turns me off to playing them. Seriously, i would pick it up in a heartbeat if the game wasnt timed for 3 days and just had story progression.
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